Booklet for Hemato-Oncologists
Case 2 (A, B) - Hyperleukocytosis resistant to steroid administration
Child, 3 years old, male, affected by ALL. At diagnosis he presented with hyperleukocytosis (WBC = 330,000/mm³) and conspicuous hepatosplenomegaly. In spite of steroid administration a progressive increase of WBC (> 600,000/mm³) was observed.
A - Which anti-hyperuricemic therapy would you consider in this case?
1. Allopurinol with hyperhydration and urine alkalinization
3. Allopurinol + Urate-oxidase
4. Allopurinol alone
B - When do you start antiuricemic treatment in general?
1. Only if WBC > 10,000/mm³
3. Always at diagnosis
4. If uric acid > 7 mg/dl
5. If renal function is impaired
» List of cases