Booklet for Hemato-Oncologists        

Case 17 (A, B) - Erroneous introduction of 300 mg of MTX during triple intrathecal therapy

A 7-year-old boy with ALL received 600 mg of i.v. MTX over 2 hours followed by triple intrathecal therapy (TIT): Ara-C 30 mg, Methylprednisolone 10 mg and MTX 300 mg instead of the prescribed 12 mg. He was transferred to the ICU, intubated and treated with phenobarbital.

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